A Candidate Hypertension Gene
نویسندگان
چکیده
منابع مشابه
A candidate hypertension gene: will SPON1 hold salt and water?
Hypertension affects 20% of the general population, and yet its etiologic basis remains unknown in the vast proportion of those affected.1 Hypertension greatly increases the risk of stroke, myocardial infarction, congestive heart failure and renal dysfunction thus making it an important focus of clinical research. Although pharmacological reductions in blood pressure have been shown to decrease...
متن کاملProstasin: a possible candidate gene for human hypertension.
BACKGROUND Prostasin, a serine protease, is suggested to be a novel mechanism regulating the epithelial sodium channel (ENaC) expressed in the distal nephron. This study aimed to evaluate whether the human prostasin gene is a novel candidate gene underlying blood pressure (BP) elevation. METHODS In a sample of healthy African-American (AA) and European-American (EA) twin subjects aged 17.6 +/...
متن کاملPhosducin - a candidate gene for stress-dependent hypertension.
Repeated exposure to stress may favor, both in experimental animals and in humans, an increase in blood pressure, leading in some instances to a true hypertensive state. It is thought that stress-induced hypertension is mediated by sympathetic nervous system activation that in turn, by exerting vasoconstrictor effects and increasing heart rate (and thus cardiac output), may promote the developm...
متن کاملStill building on candidate-gene strategy in hypertension?
In the general hypertensive population, blood pressure (BP) is a multifactorial trait, and it appears that hypertension results from increments in BP from a number of contributing variants and their interactions with the environment. In spite of numerous linkage and association studies of candidate genes for BP per se, or BP response to salt, the genetic network responsible for BP variation rem...
متن کاملG proteins and hypertension: an alternative candidate gene approach.
Hypertension affects approximately 20 to 30% of individuals in industrialized countries, and is commonly believed to develop on the basis of both genetic and environmental factors. The identification of genes susceptible to the most frequent form of hypertension, commonly referred to as "essential" hypertension, is hampered by the fact that blood pressure is a poorly defined phenotype that is m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2007
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000265134.57140.da